HUBUNGAN ANTARA MATRIX METALLOPROTEINASE-13 DAN TISSUE INHIBITOR METALLOPROTEINASE-1 PADA PASIEN PERIODONTITIS KRONIS

Introduction: Chronic periodontitis is a multifactorial disease that causes rapid destruction of the tissues supporting teeth and may lead to tooth loss. Matrix metalloproteinase-13 (MMP‐13) levels have been higher in gingival crevicular fluid chronic patients tissue inhibitor metalloproteinase-1 (TIMP‐1) an endogenous MMPs implicated inflammation. This review purpose discuss relationship between matrix periodontitis. Review: The level MMP-13 plays role pathogenesis (collagenase-3) third member collagenase subfamily it potent gelatinolytic collagenolytic enzyme expressed by different cell types. activity these primarily controlled inhibitors, known as TIMPs, which N-terminal domain able inhibit MMPs. Some studies showed associated with soft hard damage during progression balance TIMPs important degradation extracellular matrix. In healthy periodontal conditions, TIMP are generally than unhealthy MMP exceed TIMP. Conclusion: characterized increase expression disease, active sites show decrease TIMP-1 association elevation .